The Kaleiodoscope Effect

Chapter 9: The Genetic Connection

by Ronald W. Hull


The Iron Range, Upper Michigan: July, 1998

Albert loved these hot summer nights. The mosquitoes had vanished, and except for the loons on the lake, an occasional howl from the wolf pack he was nurturing, and the hooting of owls, it was silent. He had left the cabin, and was lying on the chaise lounge by the lake. The stars were as bright and many as he had seen in his youth. The weight of them above him, so close he felt that he could almost reach out and touch them, made him shudder again. For all his knowledge as an astronomer and theorist, he knew little more than he did as that youth on the hill who decided to become an astronomer.

This place had become his passion. He bought the land cheap when a copper mining operation moved out in 1984. The lake had been polluted by tailings from the mine, but some earth dams and nature had restored it to near pristine. It was now full of smallmouth bass and northerns, had a beaver colony, and supported nesting for mallards and loons. He built the log house from native white pine, designed to be comfortable during long, snowed-in periods, with a propane generator to provide electricity during frequent electrical outages. Set in a south-facing wooded slope overlooking the lake, the structure was so solar passive, he could heat it in mid winter with a small wood stove.

Once he achieved tenure, Albert left summer school to his colleagues who were always eager to earn a bit more money that teaching year round brought them. He mastered the long, two day drive, first in a used station wagon, then in a full sized van he bought new. His homestead was a lot of work, especially when he returned each May to repair the damage of the previous Winter. He seemed to find more time here to think and write. In addition to the Kaleidoscope Effect theory, he video taped his wolves and the beaver colony and wrote stories he got published in National Geographic and Outdoor Life.

Occasionally, he brought a student with him. He had to be careful though, because few shared his love for nature or understood the hard work required to live in a near wilderness. On more than one occasion, he had to put his charge on a plane for home before Memorial Day. His stars were those who, after a summer with him, went on to graduate school in the sciences. In the early years, he rarely went back after school started. Then, in 1990, he bought a used Jeep Cherokee with a winch, plow, and four wheel drive. After that, he had standing plane tickets to and from Escanaba for the Christmas Holidays. He was able to hunt in the late deer season with his father and brothers and enjoy the beauty of the early winter snow.

Jeremy was one of those students. Curious and inquisitive, he loved science. He was here to do a pond project, looking for deformed frogs that were plaguing the Upper Midwest, as an entree to graduate school in the biosciences in the fall. He was a product of the DC inner city, an unlikely candidate to enjoy the wilderness. But his mother, a staff worker for the Senator from Utah, had instilled in him a love for reading that led him to the wilderness. Except for a constant stream of questions, Jeremy was one of the stars--a big help around the place. They took turns making evening meals of fresh fish or one of the thawed out game animals Albert had shot the year before. Once a week or so, they'd head in Ironwood for a burger or pizza and a movie, then shoot pool over a beer at a friendly bar.

Jeremy had stayed inside, closed in, in the bedroom with a window ac unit. He said the heat, "... Reminded him of DC, and wanted no part of sleeping out in it."

Albert was sweating too, but eventually, he fell asleep after thinking about all those stars. He dreamed he was running with Esther up a hill, then through woods, then he lost her in a crumbling city. He awoke, feeling a damp chill, and pulled a sheet over him. The next time he stirred, there was a bright orange glow in the east and his sheet was soaked with dew. Mosquitoes had come with the cool dawn, so he beat them off and headed uphill to the cabin. The smell of hot coffee and bacon told him that Jeremy was up with the dawn too. Living so close to nature did that to you.

As he was eating the scrambled eggs Jeremy had cooked for him, Jeremy remarked, "Oh, I forgot. When I was on the Internet last night, I saw that you have email from Johns Hopkins."

"Johns Hopkins?" When Albert finished his eggs and toast with some of his Mom's wild blackberry jam, he went to investigate.

"To: repaul_ar@howard.edu

From: khundi_r@jhu.edu

Re: Our Discovery

Dear Dr. Repaul:

Congratulations! From the sample you sent us, you appear to be a direct descendant of the iceman, Otsi! You are the first and only to have his entire DNA sequence in yours. We tried to call you in Washington, DC, and then at the number in Upper Michigan, but it was busy. Please call me at 410 955-3184 at your earliest convenience. I want you to come here, at our expense, so that we can do further testing to make sure that our findings are correct.

Sincerely,

Dr. Rao Khundi, Principal Investigator
Geneome Genealogy Project
The Johns Hopkins University "

Albert was dumbstruck. "Jeremy, can you hold down the fort around here for a while? I have to go to Baltimore for a few days. You must have been chatting with Cherry when they called. Let me disconnect so that I can call." Then he realized that it was only 7:15 AM, Baltimore time. He fired off a quick email response then waited an hour to make the call.

Albert was on the plane to Detroit from Escanaba the next morning. Jeremy had gotten up at an ungodly hour to drive him there, and promised to keep the place in shape until he got back. Albert remembered seeing the ad in Science, and taking it on as a class project. Dr. Khundi was doing oncology research at Johns Hopkins. He had obtained some DNA from Otsi from the University of Innsbruck and conceived a project to track cancer in long genealogies. He was looking for people of Germanic and Italian ancestry to see if he could match them with Otsi, then follow cancer records back through the generations to see how the DNA had changed.

When Albert first brought the study to the attention of his classes, they laughed. Then, after he explained that, if they were able to glean some DNA from Lucie, Australopithecus, Leakey's find in North Africa, we'd all be related, fifteen students admitted to some European heritage. They checked into Howard's Student Clinic as a group, and had blood drawn. Then, with the required contact information, the blood was sent to Johns Hopkins. That was last March. He'd almost forgotten about it. Now he was the chosen one.

Kundhi met him alone at the airport, explaining, "I want to keep this as low key as possible. The lab is bursting with excitement already. I told them not to tell anyone, not even their families, until we got you in here for verification. All I need would for there to be some mistake and it got leaked to the press. My research would be ruined, and NIH would never fund research like mine again." He looked to Albert for understanding. Albert understood only too well.

As Khundi drove him to the medical center, Albert thought about what was happening. He remembered all the fervor over discovery of the Ice Man. He wasn't sure about that type of publicity. When they got to the lab, he was treated like he was from outer space. Khundi did the procedures himself. First, he drew blood; then, he took some skin scrapings and hair; then, finally, some biopsy material from obvious places. Then Khundi drove him to a local hotel where he'd wait for the sequencing to be replicated.

Albert got a laptop from the concierge, and an Internet connection. After taking notes for a diary of the experience, he looked up all he could find on Otsi, the ice man, on the Net, emailed Jeremy, and made arrangements to chat with him each evening. After three days he was getting tired of the hotel restaurants and cable movies. He longed to get back to his summer retreat. Then, he got the call.

"It's an absolute match. You are a direct descendant of Otsi! His voice quavered with excitement. We'll have a news conference this afternoon. Do we need to get you something to wear?"

The next three weeks were a whirlwind of talk shows and news magazines. No matter that his whole family were descendants too, he was the first one found. Dr. Khundi tried to explain that his research was to find a cure for cancer. His explanation was lost in the public's fascination that a modern day descendant of the Ice Man was still walking around among them, 5,000 years later.

Albert's brother had traced the Repaul genealogy ten years earlier. There were no Repauls in Europe. The first Repauls appeared in Pennsylvania in the early 1800s. An Earl Repaulo, from the Alsace-Lorraine, was known to have arrived in Philadelphia in 1792. Early immigrants from Europe to the United States often changed their names upon arrival. Maybe Repaulo sounded too Italian. The family remained small. Repauls moved to Ohio, then Indiana, Michigan, and finally, Upper Michigan. Khundi wanted DNA and medical histories on all Repaul family members. Worst of all, he wanted to exhume graves to trace DNA and see if the deceased died of cancer. Albert found it most distasteful, but helped recruit family members and got their permission, however he could, in the name of science.

The grave of the oldest know relative in Central Pennsylvania contained the same DNA. Death was determined to be from a hip fracture in old age. Beth Repaul was about 80. Had she come from France with Earl? There was no way of knowing.

There was cancer in Albert's family, especially in the last fifty years, but Khundi's results were inconclusive. He published them in the New England Journal of Medicine later that year.

Albert returned just in time for bow hunting season. His email was still ridiculous, but he took time from it to teach Jeremy how to use a bow. Jeremy was rewarded with a young buck. He was fascinated as he helped Albert gut the still warm animal. It was like a lab disection, only this was no frog. He would be taking venison home to his mother.

Chapter 10

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Copyright (c) 2000 Ronald W. Hull